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Pharmacogenomics: A personalized response to medication non-adherence

Pharmacogenetics or the genetic variations in the human population giving rise to a variable drug response is well-known in clinical research1. The quest for personalized medicine based on pharmacogenomics using an individual’s genetic content has gained traction since the completion of the first draft of the human genome project2,3. Pharmacogenomics-based personalized prescriptions can help in…

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Physician counseling a patient

Interventions to tackle medication non-adherence

Medication adherence, or the extent to which patients take medications as prescribed, is remarkably low and it has been reported that typically, patients adhere to about 50% of prescribed medications1. Factors causing medication non-adherence are varied and can be grouped into patient-related, therapy-related, and healthcare system-related1. Some of the common reasons are forgetfulness, adverse effects,…

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Healthcare practitioners in conversation with a patient.

Power of algorithm: Identifying high-risk non-adherent patient groups

Non-adherence to medication is a major challenge to treatment success and a significant burden on the healthcare system1-3. The existing interventions are based on retrospective measurements of non-adherence in patients already undergoing treatment and are therefore limited in improving future medication adherence4. Predictive analytics can help in identifying potentially high-risk non-adherent patient groups at the…

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HCPs in deep discussion while pointing to an iPad

Looking into the Crystal-ball: Advances in technology for improving adherence

Current technological interventions focus either on reminding the patient or on tracking the pill removal from the packaging. However, they do not address the actual act of taking the medicine1. The ingestible sensors or trackable pills have marked a technological revolution in the area of medication adherence. In addition, motion-sensor-based wearables are likely will mark…

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Measuring adherence – an “Achilles heel” in medication adherence

Adherence measurement is a complex task, which can be performed through various direct and indirect methods Each method has its advantages and limitations with no universal consensus on a gold standard technique The use of combinatorial methods might offer the best solution. Further, there is a need to optimize techniques for different populations as well…

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A friendly gathering over lunch.

Technological advancements and innovations to improve medication adherence

Medication non-adherence is an important challenge that leads to suboptimal treatment outcomes1. Using innovative technologies in interventions can help in combating this issue. Smart interventions specifically concerning packaging, monitoring, record keeping, and reminding medication are now available and can significantly improve patients’ medication adherence2. Medication adherence defined as the extent to which a patient’s behavior…

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Healthcare practitioners: A potential springboard for adherence success

Healthcare practitioners (HCPs) are uniquely positioned to deliver medication adherence interventions1. Communication between HCPs and patient is inadequate2. Enabling HCPs with the required skill-set is pivotal1. Improving adherence to medications requires a collaborative team effort from health care professionals3,4. Optimum disease management requires taking medication in the required dosage at the right time as advised…

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Healthcare practitioners absorbed in a discussion

Prescription costs are key to non-adherence: Can generics help?

Prescription costs are a potent driver for non-adherence to medication1-3. Generic substitution of prescriptions is key to lowering the out-of-pocket costs of medications4-6. Distrust in generic medications needs to be addressed to encourage their usage and reduce cost-related non-adherence7.   Cost-related non-adherence (CRNA): Cost of medicines is an overriding issue for adherence to the treatment…

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An elderly couple riding bicycle

Non-adherence to immunosuppressants in organ transplant patients

Non-adherence to medication remains a barrier to long-term graft survival in the life of solid organ transplant patients1,2. The major risk factors for non-adherence include income, complex regimen, employment status, minority race, illness perception, and mental health2,3.  Multicomponent interventions tailored to the need of patients appear to be most effective in lowering non-adherence to immunosuppressants4.…

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A group of young females excercising in a gym.

Adherence in Asthma – a victim of the episodic nature of the disease

Asthma is characterized by its episodic and unpredictable nature1. Inhalation therapy – the standard treatment of care – is not optimally adhered to by patients. The key barriers are unawareness, misconceptions, unaffordability, inaccessibility, and associated stigma1,2. Tracking adherence in asthma is also a considerable challenge. However, the upcoming smart technologies like the use of Smart-inhalers…

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Oral therapies for cancer: a boon for treatment and bane for adherence

Oral therapies have revolutionized cancer treatment with their ease of administration. However, they are prone to non-adherence as drugs are administered by patients away from health care settings1. Cancer therapies are now akin to treatments for chronic ailments, lasting for several years. Therefore, the medication adherence barriers that pertain to chronic disease have become significant…

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Two elderly people jogging and smiling

Pill reminders: Addressing non-adherence owing to forgetfulness

“You can look for external sources of motivation and that can catalyze a change, but it won’t sustain one. It has to be from internal desire.” – Jillian Michaels Medication adherence is defined by the World Health Organization as “the degree to which the person’s behavior corresponds with the agreed recommendations from a health care…

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Three healthcare practitioners in deep discussion.

Covid-19 as a teacher: Lessons learned in medication adherence

The covid-19 pandemic was catastrophic for healthcare infrastructure and it has highlighted the deficiencies in the system1. Medication non-adherence soared during the pandemic because of virus containment measures that led to disruption in healthcare services, breakdown of support network, financial constraints, and enhancement of psychological issues 2 Identifying the vulnerable, strengthening health infrastructure, and use…

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Kid looking through a microscope

Improving medication adherence through a collaborative approach with the CfBI Medical Adherence and Digital Health consortium

Abbott is proud to work with CfBI Medical Adherence and Digital Health consortium, which brings together powerful stakeholders and decision makers from across healthcare encompassing organizations from the pharmaceutical, pharmacy, contract research, technology, patient advocacy, insurance, and health care professional sectors – advised by leading academics. This is taking a collaborative pan industry approach to…

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Is nudging enough to achieve behavioral changes at short notice?

Nudging is a powerful tool in helping people make the right decisions without forcing them to do so. It has been widely used by public authorities to help the general public adopt behaviors beneficial to them, that otherwise they would tend not to adopt. In his groundbreaking book “Nudge”, Nobel prize winner Richard Thaler gives…

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Pandemic outbreak management: a behavioral science perspective

Pandemics are not new to the humankind, and the coronavirus is just the latest (and most probably not the last) of them. A considerable number of the pandemics were dealt with medically, through vaccination.1,2 This was the case for polio, smallpox, rubella, to name but few. These diseases had been killing great numbers of people…

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